Anti-angiogenic activity of rPAI-123 and vasa vasorum regression
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منابع مشابه
Molecular Medicine Antiangiogenic Activity of rPAI-123 Promotes Vasa Vasorum Regression in Hypercholesterolemic Mice Through a Plasmin-Dependent Mechanism
Rationale: The antiangiogenic activity of rPAI-123, a truncated plasminogen activator inhibitor-1 (PAI-1) protein, induces vasa vasorum collapse and significantly reduces plaque area and plaque cholesterol in hypercholesterolemic low-density lipoprotein receptor–deficient/apolipoprotein B48–deficient mice. Objective: The objective of this study was to examine rPAI-123–stimulated mechanisms that...
متن کاملThe antiangiogenic activity of rPAI-1(23) inhibits vasa vasorum and growth of atherosclerotic plaque.
Plaque vascularity has been implicated in its growth and stability. However, there is a paucity of information regarding the origin of plaque vasculature and the role of vasa vasorum in plaque growth. To inhibit growth of vasa vasorum in atherogenic mice and assess its effect on plaque growth, we used a truncated plasminogen activator inhibitor (PAI)-1 protein, rPAI-1(23), that has significant ...
متن کاملAntiangiogenic activity of rPAI-1(23) promotes vasa vasorum regression in hypercholesterolemic mice through a plasmin-dependent mechanism.
RATIONALE The antiangiogenic activity of rPAI-1(23), a truncated plasminogen activator inhibitor-1 (PAI-1) protein, induces vasa vasorum collapse and significantly reduces plaque area and plaque cholesterol in hypercholesterolemic low-density lipoprotein receptor-deficient/apolipoprotein B48-deficient mice. OBJECTIVE The objective of this study was to examine rPAI-1(23)-stimulated mechanisms ...
متن کاملFibroblast growth factor-2 is required for vasa vasorum plexus stability in hypercholesterolemic mice.
OBJECTIVE Vasa vasorum are angiogenic in advanced stages of human atherosclerosis and hypercholesterolemic mouse models. Fibroblast growth factor-2 (FGF-2) is the predominant angiogenic growth factor in the adventitia and plaque of hypercholesterolemic low-density lipoprotein receptor-deficient/apolipoprotein B(100/100) mice (DKO). FGF-2 seems to play a role in the formation of a distinct vasa ...
متن کاملVasa Vasorum Imaging
The majority of acute coronary syndromes are the result of coronary plaque rupture. Recent studies have revealed the presence of neovascularization in and around the plaque to be a common feature of presumed rupture-prone (vulnerable) plaques. Intravascular ultrasound combined with contrast enhancement agents has been shown to be useful for the detection and quantification of vasa vasorum (VV) ...
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ژورنال
عنوان ژورنال: Trends in Cardiovascular Medicine
سال: 2013
ISSN: 1050-1738
DOI: 10.1016/j.tcm.2012.09.009